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Enhancing regeneration after acute kidney injury by promoting cellular dedifferentiation in zebrafish

Acute kidney injury (AKI) is a serious disorder for which there are limited treatment options. Following injury, native nephrons display limited regenerative capabilities, relying on the dedifferentiation and proliferation of renal tubular epithelial cells (RTECs) that survive the insult. Previously...

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Autori principali: Lauren Brilli Skvarca, Hwa In Han, Eugenel B. Espiritu, Maria A. Missinato, Elizabeth R. Rochon, Michael D. McDaniels, Abha S. Bais, Beth L. Roman, Joshua S. Waxman, Simon C. Watkins, Alan J. Davidson, Michael Tsang, Neil A. Hukriede
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Company of Biologists 2019-04-01
Serie:Disease Models & Mechanisms
Soggetti:
Acute kidney injury
Macrophages
Renal proximal tubule cell
Cardiovascular
HDAC inhibitor
Therapeutic
Accesso online:http://dmm.biologists.org/content/12/4/dmm037390
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