The Shigella flexneri effector IpaH1.4 facilitates RNF213 degradation and protects cytosolic bacteria against interferon-induced ubiquitylation

A central signal that marshals host defense against many infections is the lymphocyte-derived cytokine interferon-gamma (IFNγ). The IFNγ receptor is expressed on most human cells, and its activation leads to the expression of antimicrobial proteins that execute diverse cell-autonomous immune program...

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Hlavní autoři:	Luz Saavedra-Sanchez, Mary S Dickinson, Shruti S Apte, Yifeng Zhang, Maarten De Jong, Samantha Skavicus, Nicholas S Heaton, Neal M Alto, Jorn Coers
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	eLife Sciences Publications Ltd 2025-11-01
Edice:	eLife
Témata:	Shigella RNF213 ubiquitin autophagy xenophagy E3 ligase
On-line přístup:	https://elifesciences.org/articles/102714
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