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Chemical synthesis of H2 relaxin analogue carrying an affinity tag through click chemistry-assisted diaminodiacid strategy

H2 relaxin is an important member of the insulin superfamily, but little is known about how H2-relaxin activates the RXFP1 receptor. Affinity-tag containing peptide probes could separate receptor from cell/tissue lysate through pull-down methods, and the probe-receptor complex could be applied in th...

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Main Authors: Yuan Gao, Junjiang Li, Xiaona Han, Ning Wang, Jun Wang, Yi-Ming Li
Format: Artigo
Language:Inglês
Published: Elsevier 2025-03-01
Series:Results in Chemistry
Subjects:
H2 relaxin
Peptide probes
Diaminodiacid
Click chemistry
Online Access:http://www.sciencedirect.com/science/article/pii/S2211715625001468
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