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Activated sympathetic nerve post stroke downregulates Toll-like receptor 5 and disrupts the gut mucosal barrier

Summary: The gut permeability significantly increases after ischemic stroke, partly due to disrupted mucosal barrier, but the mechanism remains elusive. Here, we found that the mucus disruption starts at 2 h post stroke, whereas goblet cell functions remain intact. Meanwhile, the flagellated bacteri...

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Principais autores: Huidi Wang, Jie Li, Guangyan Wu, Xiaofei Lin, Jiaying Chen, Jingru Liang, Jiahui Zhang, Xiaoxia Luo, Hongyun Mao, Jiahui Xie, Zhuang Li, Hongwei Zhou, Kaiyu Xu, Jia Yin, Yan He
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2024-10-01
coleção:Cell Reports Medicine
Assuntos:
ischemic stroke
intestinal barrier
Toll-like receptor 5
flagellated bacteria
sympathetic nerve
mucus layer
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2666379124004841
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