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Interferon-gamma release assay conversion after Mycobacterium tuberculosis exposure specifically associates with greater risk of progression to tuberculosis: A prospective cohort study in Leicester, UK

Objectives: We investigated whether quantifying the serial QuantiFERON-TB Gold (QFT) response improves tuberculosis (TB) risk stratification in pulmonary TB (PTB) contacts. Methods: A total of 297 untreated adult household PTB contacts, QFT tested at baseline and 3 months after index notification, w...

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Principais autores: Jee Whang Kim, Joshua Nazareth, Joanne Lee, Hemu Patel, Gerrit Woltmann, Raman Verma, Anne O'Garra, Pranabashis Haldar
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2024-04-01
coleção:International Journal of Infectious Diseases
Assuntos:
Tuberculosis infection
Tuberculosis
IGRA
QuantiFERON
TB risk
Incidence
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S1201971224000535
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