Effective Tumor Targeting by EphA2-Agonist-Biotin-Streptavidin Conjugates
We recently reported on a potent synthetic agent, 135H11, that selectively targets the receptor tyrosine kinase, EphA2. While 135H11 possesses a relatively high binding affinity for the ligand-binding domain of EphA2 (Kd~130 nM), receptor activation in the cell required the synthesis of dimeric vers...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
MDPI AG
2021-06-01
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| Schriftenreihe: | Molecules |
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| Online-Zugang: | https://www.mdpi.com/1420-3049/26/12/3687 |
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