SPIN1, negatively regulated by miR-148/152, enhances Adriamycin resistance via upregulating drug metabolizing enzymes and transporter in breast cancer

Abstract Background Spindlin1 (SPIN1), a protein highly expressed in several human cancers, has been correlated with tumorigenesis and development. Alterations of drug metabolizing enzymes and drug transporters are major determinants of chemoresistance in tumor cells. However, whether the metabolizi...

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Detalhes bibliográficos

Principais autores:	Xu Chen, Ya-Wen Wang, Peng Gao
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2018-05-01
coleção:	Journal of Experimental & Clinical Cancer Research
Assuntos:	Breast cancer Adriamycin resistance SPIN1 miR-148/152 Drug metabolizing enzymes Drug transporter
Acesso em linha:	http://link.springer.com/article/10.1186/s13046-018-0748-9
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