Analyses on clustering of the conserved residues at protein-RNA interfaces and its application in binding site identification

Abstract Background The maintenance of protein structural stability requires the cooperativity among spatially neighboring residues. Previous studies have shown that conserved residues tend to occur clustered together within enzyme active sites and protein-protein/DNA interfaces. It is possible that...

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Autori principali:	Zhen Yang, Xueqing Deng, Yang Liu, Weikang Gong, Chunhua Li
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2020-02-01
Serie:	BMC Bioinformatics
Soggetti:	Protein-RNA interfaces Conserved residues Clustering characteristics Hot spot residues Binding site identification
Accesso online:	http://link.springer.com/article/10.1186/s12859-020-3398-9
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