Modic Change Bone Marrow Neutrophils Are Activated and Degrade Cartilage Endplates

ABSTRACT Background Vertebral endplate bone marrow lesions (Modic changes, MC) are linked to vertebrogenic pain and to structural defects of the bony and cartilaginous endplates (CEP). However, the immune mechanisms that may perpetuate CEP damage in MC remain unclear. Objective To (i) characterize n...

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Detalhes bibliográficos

Principais autores:	Irina Heggli, Tamara Mengis, Jan Devan, Nick Herger, Mazda Farshad, Mohamed Habib, Christopher P. Ames, Oliver Distler, Aaron J. Fields, Stefan Dudli
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2026-03-01
coleção:	JOR Spine
Assuntos:	degeneration endplate inflammation modic change neutrophils
Acesso em linha:	https://doi.org/10.1002/jsp2.70170
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