Circulating tumour DNA detects somatic variants contributing to spatial and temporal intra-tumoural heterogeneity in head and neck squamous cell carcinoma

BackgroundAs circulating tumour DNA (ctDNA) liquid biopsy analysis is increasingly incorporated into modern oncological practice, establishing the impact of genomic intra-tumoural heterogeneity (ITH) upon data output is paramount. Despite advances in other cancer types the evidence base in head and...

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Principais autores:	Karl F. B. Payne, Peter Brotherwood, Harini Suriyanarayanan, Jill M. Brooks, Nikolaos Batis, Andrew D. Beggs, Deena M. A. Gendoo, Hisham Mehanna, Paul Nankivell
格式:	Artigo
語言:	Inglês
出版:	Frontiers Media S.A. 2024-04-01
叢編:	Frontiers in Oncology
主題:	head and neck cancer HNSCC (head and neck squamous cell carcinoma) liquid biopsy Ctdna (circulating tumour DNA) intra-tumor heterogeneity temporal heterogeneity
在線閱讀:	https://www.frontiersin.org/articles/10.3389/fonc.2024.1374816/full
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