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Caspases and programmed cell death in sepsis: mechanisms, pathophysiology, and therapeutic targets

Sepsis represents a critical medical condition characterized by organ impairment resulting from an uncontrolled systemic reaction to pathogenic infection, posing substantial difficulties in intensive care management. As a key pathological mechanism, programmed cell death (PCD) critically contributes...

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Principais autores: Haibei He, Xiuli Xie, Lisui Zhou, Yumeng Lin, Aijun Liu, Peng Guo, Yu Zhu, Yu Tang, Zhongyu Han, Yi Wang, Haoran Chen
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2026-07-01
coleção:Frontiers in Immunology
Assuntos:
apoptosis
caspase
necroptosis
PANoptosis
pyroptosis
sepsis
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1879033/full
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