Systematic in vivo candidate evaluation uncovers therapeutic targets for LMNA dilated cardiomyopathy and risk of Lamin A toxicity

Abstract Background Dilated cardiomyopathy (DCM) is a severe, non-ischemic heart disease which ultimately results in heart failure (HF). Decades of research on DCM have revealed diverse aetiologies. Among them, familial DCM is the major form of DCM, with pathogenic variants in LMNA being the second...

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Detalhes bibliográficos

Principais autores:	Chia Yee Tan, Pui Shi Chan, Hansen Tan, Sung Wei Tan, Chang Jie Mick Lee, Jiong-Wei Wang, Shu Ye, Hendrikje Werner, Ying Jie Loh, Yin Loon Lee, Matthew Ackers-Johnson, Roger S. Y. Foo, Jianming Jiang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2023-10-01
coleção:	Journal of Translational Medicine
Assuntos:	Dilated cardiomyopathy Lamin A/C Sun1 Gene therapy AAV Fibrosis
Acesso em linha:	https://doi.org/10.1186/s12967-023-04542-4
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