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Assessment of synaptic loss in mouse models of β-amyloid and tau pathology using [18F]UCB-H PET imaging

Objective: In preclinical research, the use of [18F]Fluorodesoxyglucose (FDG) as a biomarker for neurodegeneration may induce bias due to enhanced glucose uptake by immune cells. In this study, we sought to investigate synaptic vesicle glycoprotein 2A (SV2A) PET with [18F]UCB-H as an alternative pre...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Letizia Vogler, Anna Ballweg, Bernd Bohr, Nils Briel, Karin Wind, Melissa Antons, Lea H. Kunze, Johannes Gnörich, Simon Lindner, Franz-Josef Gildehaus, Karlheinz Baumann, Peter Bartenstein, Guido Boening, Sibylle I. Ziegler, Johannes Levin, Andreas Zwergal, Günter U. Höglinger, Jochen Herms, Matthias Brendel
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2023-01-01
Schriftenreihe:NeuroImage: Clinical
Schlagworte:
SV2A
PET
Synaptic loss
Tau
Aβ
Online-Zugang:http://www.sciencedirect.com/science/article/pii/S2213158223001754
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