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Comparative permeability of three saikosaponins and corresponding saikogenins in Caco-2 model by a validated UHPLC-MS/MS method

Saikosaponins (SSs) are the main active components extracted from Bupleuri Radix (BR) which has been used as an important herbal drug in Asian countries for thousands of years. It has been reported that the intestinal bacteria plays an important role in the in vivo disposal of oral SSs. Although the...

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Principais autores: Siqi Ren, Jingjing Liu, Yunwen Xue, Mei Zhang, Qiwei Liu, Jie Xu, Zunjian Zhang, Rui Song
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021-08-01
coleção:Journal of Pharmaceutical Analysis
Assuntos:
Bupleuri Radix
Saikosaponin
Saikogenin
UHPLC-MS/MS
Caco-2 cells
Permeability
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2095177920301039
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