High Throughput Screening of FDA-Approved Drug Library Reveals the Compounds that Promote IRF3-Mediated Pro-Apoptotic Pathway Inhibit Virus Replication

Interferon (IFN) regulatory factor 3 (IRF3) is the key transcription factor for the induction of IFN and antiviral genes. The absence of antiviral genes in IRF3 deficiency leads to susceptibility to a wide range of viral infections. Previously, we uncovered a function for nontranscriptional IRF3 (nt...

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Главные авторы:	Anna Glanz, Karan Chawla, Stephanie Fabry, Gayatri Subramanian, Julie Garcia, Bryanna Jay, Jacob Ciricillo, Ritu Chakravarti, R. Travis Taylor, Saurabh Chattopadhyay
Формат:	Artigo
Язык:	Inglês
Опубликовано:	MDPI AG 2020-04-01
Серии:	Viruses
Предметы:	IRF3 RIPA antiviral innate immunity drug screen interferon
Online-ссылка:	https://www.mdpi.com/1999-4915/12/4/442
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