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The unfolded protein response is activated in the olfactory system in Alzheimer’s disease

Abstract Olfactory dysfunction is an early and prevalent symptom of Alzheimer’s disease (AD) and the olfactory bulb is a nexus of beta-amyloid plaque and tau neurofibrillary tangle (NFT) pathology during early AD progression. To mitigate the accumulation of misfolded proteins, an endoplasmic reticul...

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Principais autores: Helen C. Murray, Birger Victor Dieriks, Molly E. V. Swanson, Praju Vikas Anekal, Clinton Turner, Richard L. M. Faull, Leonardo Belluscio, Alan Koretsky, Maurice A. Curtis
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2020-07-01
coleção:Acta Neuropathologica Communications
Assuntos:
Alzheimer’s disease
Unfolded protein response
Olfactory bulb
Anterior olfactory nucleus
PERK
eIF2α
Acesso em linha:http://link.springer.com/article/10.1186/s40478-020-00986-7
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