Polysulfide and persulfide-mediated activation of the PERK-eIF2α-ATF4 pathway increases Sestrin2 expression and reduces methylglyoxal toxicity
Unfolded protein response (UPR) is activated in cells under endoplasmic reticulum (ER) stress. One sensor protein involved in this response is PERK, which is activated through its redox-dependent oligomerization. Prolonged UPR activation is associated with the development and progression of various...
Enregistré dans:
| Auteurs principaux: | , , |
|---|---|
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Elsevier
2025-02-01
|
| Collection: | Redox Biology |
| Sujets: | |
| Accès en ligne: | http://www.sciencedirect.com/science/article/pii/S2213231724004282 |
| Tags: |
Pas de tags, Soyez le premier à ajouter un tag!
|