Sculpting the tumour microenvironment by combining radiotherapy and ATR inhibition for curative-intent adjuvant immunotherapy

Abstract The combination of radiotherapy/chemoradiotherapy and immune checkpoint blockade can result in poor outcomes in patients with locally advanced head and neck squamous cell carcinoma (HNSCC). Here, we show that combining ATR inhibition (ATRi) with radiotherapy (RT) increases the frequency of...

תיאור מלא

מידע ביבליוגרפי

Principais autores:	Emmanuel C. Patin, Pablo Nenclares, Charleen Chan Wah Hak, Magnus T. Dillon, Anton Patrikeev, Martin McLaughlin, Lorna Grove, Shane Foo, Heba Soliman, Joao P. Barata, Joanna Marsden, Holly Baldock, Jim Gkantalis, Victoria Roulstone, Joan Kyula, Amy Burley, Lisa Hubbard, Malin Pedersen, Simon A. Smith, Eleanor Clancy-Thompson, Alan A. Melcher, Masahiro Ono, Antonio Rullan, Kevin J. Harrington
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Nature Portfolio 2024-08-01
סדרה:	Nature Communications
גישה מקוונת:	https://doi.org/10.1038/s41467-024-51236-6
תגים:	הוספת תג אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!