Paracrine rescue of MYR1-deficient Toxoplasma gondii mutants reveals limitations of pooled in vivo CRISPR screens

Toxoplasma gondii is an intracellular parasite that subverts host cell functions via secreted virulence factors. Up to 70% of parasite-controlled changes in the host transcriptome rely on the MYR1 protein, which is required for the translocation of secreted proteins into the host cell. Mice infected...

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Principais autores:	Francesca Torelli, Diogo M da Fonseca, Simon W Butterworth, Joanna C Young, Moritz Treeck
格式:	Artigo
語言:	Inglês
出版:	eLife Sciences Publications Ltd 2024-12-01
叢編:	eLife
主題:	Toxoplasma crispr screening immunology parasitology microbiology infection
在線閱讀:	https://elifesciences.org/articles/102592
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