Gene-expression profiling of individuals resilient to Alzheimer's disease reveals higher expression of genes related to metallothionein and mitochondrial processes and no changes in the unfolded protein response

Abstract Some individuals show a discrepancy between cognition and the amount of neuropathological changes characteristic for Alzheimer’s disease (AD). This phenomenon has been referred to as ‘resilience’. The molecular and cellular underpinnings of resilience remain poorly understood. To obtain an...

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Main Authors:	Luuk E. de Vries, Aldo Jongejan, Jennifer Monteiro Fortes, Rawien Balesar, Annemieke J. M. Rozemuller, Perry D. Moerland, Inge Huitinga, Dick F. Swaab, Joost Verhaagen
Format:	Artigo
Language:	Inglês
Published:	BMC 2024-04-01
Series:	Acta Neuropathologica Communications
Subjects:	Alzheimer’s disease Resilience Post-mortem tissue RNA-sequencing Metallothionein Mitochondria
Online Access:	https://doi.org/10.1186/s40478-024-01760-9
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