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Shear stress activates ATOH8 via autocrine VEGF promoting glycolysis dependent-survival of colorectal cancer cells in the circulation

Abstract Background Metastasis and recurrence, wherein circulating tumour cells (CTCs) play an important role, are the leading causes of death in colorectal cancer (CRC). Metastasis-initiating CTCs manage to maintain intravascular survival under anoikis, immune attack, and importantly shear stress;...

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Kaydedildi:
Asıl Yazarlar: Qiong Huang, Shaowei Li, Xingbin Hu, Mengting Sun, Qijing Wu, Huiru Dai, Yujing Tan, Fei Sun, Chunlin Wang, Xiaoxiang Rong, Wangjun Liao, Jianjun Peng, Jianjun Xiao, Li Huang, Jiao Wang, Bishan Liang, Kelin Lin, Yajing Liu, Min Shi
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BMC 2020-01-01
Seri Bilgileri:Journal of Experimental & Clinical Cancer Research
Konular:
Laminar shear stress
Colorectal cancer
ATOH8
Glycolysis
VEGF
Online Erişim:https://doi.org/10.1186/s13046-020-1533-0
Etiketler: Etiketle
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