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Targeting Hyaluronan Signaling Overcomes Primary Effusion Lymphoma Cells Resistance to Rapamycin

Abstract The oncogenic γ-herpesvirus known as the Kaposi’s sarcoma-associated herpesvirus (KSHV) is a principal causative agent of several cancers arising in patients with compromised immune systems. One of KSHV-related malignancies, primary effusion lymphoma (PEL), comprises transformed B cells har...

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Main Authors: Jungang Chen, Margaret Qin, Jiaojiao Fan, Shengyu Mu, Lu Dai, Zhiqiang Qin
Format: Artigo
Language:Inglês
Published: BMC 2026-05-01
Series:Biological Procedures Online
Subjects:
KSHV
PEL
Hyaluronan
Rapamycin
Resistance
Online Access:https://doi.org/10.1186/s12575-026-00346-0
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