GNODEVAE: a graph-based ODE-VAE enhances clustering for single-cell data

Abstract Background Single-cell RNA sequencing analysis faces critical challenges including high dimensionality, sparsity, and complex topological relationships between cells. Current methods struggle to simultaneously preserve global structure, model cellular dynamics, and handle technical noise ef...

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Podrobná bibliografie

Hlavní autoři:	Zeyu Fu, Chunlin Chen, Song Wang, Junping Wang, Shilei Chen
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2025-08-01
Edice:	BMC Genomics
Témata:	Graph attention networks Neural ordinary differential equation Variational autoencoders Clustering ScRNA-seq ScATAC-seq
On-line přístup:	https://doi.org/10.1186/s12864-025-11946-7
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