Mechanism of actin-dependent activation of nucleotidyl cyclase toxins from bacterial human pathogens
The nucleotidyl cyclase toxin exoenzyme Y (ExoY), which is secreted by the human pathogens Pseudomonas aeruginosa and Vibrio vulnificus is activated by actin. Here, the authors present the cryo-EM structures of PaExoY bound to F-actin and VvExoY in complex with G-actin-profilin. These structures tog...
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| Principais autores: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Portfolio
2021-11-01
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| coleção: | Nature Communications |
| Acesso em linha: | https://doi.org/10.1038/s41467-021-26889-2 |
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