Deciphering the immune heterosis mechanism against Mycobacterium tuberculosis infection in hybrid mice based on allele-specific expression

Abstract Host genetic background plays a decisive role in susceptibility to pathogens, and hybrid offspring often exhibit heterosis that surpasses parental phenotypes. However, the underlying regulatory mechanisms remain poorly understood. In this study, we generated an F1 hybrid mouse model by cros...

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Detalhes bibliográficos

Principais autores:	Haoqi Wang, Xianglong Shi, Jinxia Dai, Gang Cao, Xiaofeng Wu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2026-04-01
coleção:	Animal Diseases
Assuntos:	Mycobacterium tuberculosis Innate immunity Parent-of-origin effects Single-nucleotide polymorphism Allele-specific expression Heterosis
Acesso em linha:	https://doi.org/10.1186/s44149-026-00231-z
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