Ancestral reconstruction reveals catalytic inactivation of activation-induced cytidine deaminase concomitant with cold water adaption in the Gadiformes bony fish

Abstract Background Antibody affinity maturation in vertebrates requires the enzyme activation-induced cytidine deaminase (AID) which initiates secondary antibody diversification by mutating the immunoglobulin loci. AID-driven antibody diversification is conserved across jawed vertebrates since bony...

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Detalhes bibliográficos

Principais autores:	Atefeh Ghorbani, S. Javad Khataeipour, Monica H. Solbakken, David N. G. Huebert, Minasadat Khoddami, Khalil Eslamloo, Cassandra Collins, Tiago Hori, Sissel Jentoft, Matthew L. Rise, Mani Larijani
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2022-12-01
coleção:	BMC Biology
Assuntos:	Antibody evolution Ancestral enzymes DNA editing Innate and adaptive immunity Enzyme evolution
Acesso em linha:	https://doi.org/10.1186/s12915-022-01489-8
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