Short Overview on the Involvement of Lipid Peroxidation Product 4-Hydroxynonenal in Diverse Pathways of Cell Death

The oxidation of lipids, notably of polyunsaturated fatty acids (PUFAs), under oxidative stress is a self-catalyzed chain reaction that generates reactive aldehydes, among which 4-hydroxynonenal (4-HNE) is considered to act as a second messenger of free radicals. The pleiotropic effects of 4-HNE, wh...

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Main Authors: Morana Jaganjac, Anita Stojanovic Markovic, Nicola Deiana, Neven Zarkovic
Formato: Artigo
Idioma:Inglês
Publicado: IMR Press 2025-09-01
Series:Frontiers in Bioscience-Landmark
Assuntos:
oxidative stress
cell death
apoptosis
necrosis
ferroptosis
Acceso en liña:https://www.imrpress.com/journal/FBL/30/9/10.31083/FBL37139
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