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Hydroxygenkwanin Inhibits Class I HDAC Expression and Synergistically Enhances the Antitumor Activity of Sorafenib in Liver Cancer Cells

Abnormal histone deacetylase (HDAC) expression is closely related to cancer development and progression. Many HDAC inhibitors have been widely used in cancer treatment; however, severe side effects often limit their clinical application. In this study, we attempted to identify natural compounds with...

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Principais autores: Chi-Yuan Chen, Chin-Chuan Chen, Wen-Yu Chuang, Yann-Lii Leu, Shir-Hwa Ueng, Chuen Hsueh, Chau-Ting Yeh, Tong-Hong Wang
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020-02-01
coleção:Frontiers in Oncology
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Acesso em linha:https://www.frontiersin.org/article/10.3389/fonc.2020.00216/full
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