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Statine-based peptidomimetic compounds as inhibitors for SARS-CoV-2 main protease (SARS-CoV‑2 Mpro)

Abstract COVID-19 is a multisystemic disease caused by the SARS-CoV-2 airborne virus, a member of the Coronaviridae family. It has a positive sense single-stranded RNA genome and encodes two non-structural proteins through viral cysteine-proteases processing. Blocking this step is crucial to control...

Ausführliche Beschreibung

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Hauptverfasser: Pedro Henrique R. de A. Azevedo, Priscila G. Camargo, Larissa E. C. Constant, Stephany da S. Costa, Celimar Sinézia Silva, Alice S. Rosa, Daniel D. C. Souza, Amanda R. Tucci, Vivian N. S. Ferreira, Thamara Kelcya F. Oliveira, Nathalia R. R. Borba, Carlos R. Rodrigues, Magaly G. Albuquerque, Luiza R. S. Dias, Rafael Garrett, Milene D. Miranda, Diego Allonso, Camilo Henrique da S. Lima, Estela Maris F. Muri
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Portfolio 2024-04-01
Schriftenreihe:Scientific Reports
Online-Zugang:https://doi.org/10.1038/s41598-024-59442-4
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