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Rapid identification of malaria vaccine candidates based on alpha-helical coiled coil protein motif.

To identify malaria antigens for vaccine development, we selected alpha-helical coiled coil domains of proteins predicted to be present in the parasite erythrocytic stage. The corresponding synthetic peptides are expected to mimic structurally "native" epitopes. Indeed the 95 chemically synthesized...

Ausführliche Beschreibung

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Hauptverfasser: Viviane Villard, George W Agak, Géraldine Frank, Ali Jafarshad, Catherine Servis, Issa Nébié, Sodiomon B Sirima, Ingrid Felger, Myriam Arevalo-Herrera, Socrates Herrera, Frederic Heitz, Volker Bäcker, Pierre Druilhe, Andrey V Kajava, Giampietro Corradin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science (PLoS) 2007-07-01
Schriftenreihe:PLoS ONE
Online-Zugang:https://doi.org/10.1371/journal.pone.0000645
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