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Early-Stage Staphylococcus aureus Bloodstream Infection Causes Changes in the Concentrations of Lipoproteins and Acute-Phase Proteins and Is Associated with Low Antibody Titers against Bacterial Virulence Factors

ABSTRACT Systemic and quantitative investigations of human plasma proteins (proteomics) and Staphylococcus aureus-specific antibodies (immunoproteomics) provide complementary information and hold promise for the discovery of biomarkers in Staphylococcus aureus bloodstream infection (SABSI). Usually,...

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Principais autores: Stephan Michalik, Nandakumar Sundaramoorthy, Annette Murr, Maren Depke, Uwe Völker, Barbara M. Bröker, Hege Vangstein Aamot, Frank Schmidt
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2020-02-01
Serier:mSystems
Fag:
DIA mass spectrometry
Staphylococcus aureus
biomarker
bloodstream infections
immunoproteomics
proteomics
Online adgang:https://journals.asm.org/doi/10.1128/msystems.00632-19
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