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Tetramethylpyrazine Induces Apoptosis and Inhibits Proliferation of Hypertrophic Scar-Derived Fibroblasts via Inhibiting the Phosphorylation of AKT

Hypertrophic scar (HS) is a serious fibrotic skin disease and often considered as a kind of benign skin tumor. Tetramethylpyrazine (TMP), the main chemical composition of the traditional Chinese medicine Chuanxiong Rhizoma, has shown significant clinical benefits in the treatment of fibrosis disease...

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Principais autores: Xue Wu, Zheng Wang, Gaofeng Wu, Xiaofan Xu, Jian Zhang, Yan Li, Hong Zhang, Shuzhen Guo
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020-05-01
coleção:Frontiers in Pharmacology
Assuntos:
tetramethylpyrazine
hypertrophic scar-derived fibroblasts
apoptosis
hypertrophic scar
AKT
Acesso em linha:https://www.frontiersin.org/article/10.3389/fphar.2020.00602/full
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