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Single Nucleotide Polymorphism in KIR2DL1 Is Associated With HLA-C Expression in Global Populations

Regulation of NK cell activity is mediated through killer-cell immunoglobulin-like receptors (KIR) ability to recognize human leukocyte antigen (HLA) class I molecules as ligands. Interaction of KIR and HLA is implicated in viral infections, autoimmunity, and reproduction and there is growing eviden...

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Principais autores: Luciana de Brito Vargas, Renata M. Dourado, Leonardo M. Amorim, Brenda Ho, Verónica Calonga-Solís, Hellen C. Issler, Wesley M. Marin, Marcia H. Beltrame, Maria Luiza Petzl-Erler, Jill A. Hollenbach, Danillo G. Augusto
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020-08-01
coleção:Frontiers in Immunology
Assuntos:
NK cells
KIR
natural selection
linkage disequilibrium
coevolution
expression
Acesso em linha:https://www.frontiersin.org/article/10.3389/fimmu.2020.01881/full
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