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Exogenous kisspeptin-10 treatment shows pleiotropy via induction of KISS1 expression, metastasis suppression, and promotes apoptosis in triple-negative breast cancer

Abstract Triple-negative breast cancer (TNBC) is an aggressive subtype lacking ER, PR, and HER2 receptors making it highly clinically challenging subtype pf breast cancer. In this study, we investigated the effect of exogenous Kisspeptin-10 (Kp-10), on MDA-MB-231 and MDA-MB-468 cells. TNBC cells usi...

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Huvudupphov: Hetvi Shah, Adikrishna Murali Mohan, Lipi Buch, A. V. Ramachandran, Parth Pandya
Materialtyp: Artigo
Språk:Inglês
Utgiven: Nature Portfolio 2025-10-01
Serie:Scientific Reports
Ämnen:
Kisspeptin-10
Transcription factors
Signalling molecules
EMT markers
Apoptosis
Länkar:https://doi.org/10.1038/s41598-025-19140-1
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