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Acquisition of lipid metabolic capability in hepatocyte-like cells directly induced from mouse fibroblasts

Recently, the numbers of patients with non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) have increased worldwide. NAFLD and NASH are known as risk factors for liver cirrhosis and hepatocellular carcinoma. Because many factors can promote the progression of NAFLD and...

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Principais autores: Shizuka eMiura, Atsushi eSuzuki
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2014-08-01
Serier:Frontiers in Cell and Developmental Biology
Fag:
Lipid Metabolism
Liver
fibroblast
reprogramming
hepatocyte
iHep cell
Online adgang:http://journal.frontiersin.org/Journal/10.3389/fcell.2014.00043/full
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