A secretory form of Parkin‐independent mitophagy contributes to the repertoire of extracellular vesicles released into the tumour interstitial fluid in vivo

Abstract We characterized the in vivo interstitial fluid (IF) content of extracellular vesicles (EVs) using the GFP‐4T1 syngeneic murine cancer model to study EVs in‐transit to the draining lymph node. GFP labelling confirmed the IF EV tumour cell origin. Molecular analysis revealed an abundance of...

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Detalhes bibliográficos

Principais autores:	Marissa Howard, James Erickson, Zachary Cuba, Shawn Kim, Weidong Zhou, Purva Gade, Rachel Carter, Kelsey Mitchell, Heather Branscome, Daivik Siddhi, Fatimah Alanazi, Yuriy Kim, Robyn P. Araujo, Amanda Haymond, Alessandra Luchini, Fatah Kashanchi, Lance A. Liotta
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2022-07-01
coleção:	Journal of Extracellular Vesicles
Assuntos:	autophagosome autophagy breast cancer extracellular vesicle mitochondria mitophagy
Acesso em linha:	https://doi.org/10.1002/jev2.12244
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