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Synergistic Effect of Doxorubicin and siRNA-Mediated Silencing of Mcl-1 Using Cationic Niosomes against 3D MCF-7 Spheroids

Chemotherapy is a vital option for cancer treatment; however, its therapeutic outcomes are limited by dose-dependent toxicity and the occurrence of chemoresistance. siRNAs have emerged as an attractive therapeutic option enabling specific interference with target genes. Combination therapy using che...

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Principais autores: Supusson Pengnam, Samarwadee Plianwong, Prasopchai Patrojanasophon, Widchaya Radchatawedchakoon, Boon-ek Yingyongnarongkul, Praneet Opanasopit, Purin Charoensuksai
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2021-04-01
Serier:Pharmaceutics
Fag:
siRNA
Mcl-1
cationic niosomes
combination chemotherapy
breast cancer
Online adgang:https://www.mdpi.com/1999-4923/13/4/550
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