Epithelial Sodium Channel-α Mediates the Protective Effect of the TNF-Derived TIP Peptide in Pneumolysin-Induced Endothelial Barrier Dysfunction

BackgroundStreptococcus pneumoniae is a major etiologic agent of bacterial pneumonia. Autolysis and antibiotic-mediated lysis of pneumococci induce release of the pore-forming toxin, pneumolysin (PLY), their major virulence factor, which is a prominent cause of acute lung injury. PLY inhibits alveol...

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Detalhes bibliográficos

Principais autores:	Istvan Czikora, Abdel A. Alli, Supriya Sridhar, Michael A. Matthay, Helena Pillich, Martina Hudel, Besim Berisha, Boris Gorshkov, Maritza J. Romero, Joyce Gonzales, Guangyu Wu, Yuqing Huo, Yunchao Su, Alexander D. Verin, David Fulton, Trinad Chakraborty, Douglas C. Eaton, Rudolf Lucas
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2017-07-01
coleção:	Frontiers in Immunology
Assuntos:	epithelial sodium channel non-selective cation channel TNF pneumonia pneumolysin endothelial barrier function
Acesso em linha:	http://journal.frontiersin.org/article/10.3389/fimmu.2017.00842/full
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