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Differential Monocyte Actuation in a Three‐Organ Functional Innate Immune System‐on‐a‐Chip

Abstract A functional, human, multiorgan, pumpless, immune system‐on‐a‐chip featuring recirculating THP‐1 immune cells with cardiomyocytes, skeletal muscle, and liver in separate compartments in a serum‐free medium is developed. This in vitro platform can emulate both a targeted immune response to t...

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Principais autores: Trevor Sasserath, John W. Rumsey, Christopher W. McAleer, Lee Richard Bridges, Christopher J. Long, Daniel Elbrecht, Franz Schuler, Adrian Roth, Christina Bertinetti‐LaPatki, Michael L. Shuler, James J. Hickman
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley 2020-07-01
coleção:Advanced Science
Assuntos:
animal model alternatives
functional data
human‐on‐a‐chip
immune system‐on‐a‐chip
in vitro platforms
multiorgan systems
Acesso em linha:https://doi.org/10.1002/advs.202000323
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