The distinct conformational dynamics of K-Ras and H-Ras A59G.
Ras proteins regulate signaling cascades crucial for cell proliferation and differentiation by switching between GTP- and GDP-bound conformations. Distinct Ras isoforms have unique physiological functions with individual isoforms associated with different cancers and developmental diseases. Given th...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science (PLoS)
2010-09-01
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| Serie: | PLoS Computational Biology |
| Accesso online: | https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000922&type=printable |
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