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Stochastic epithelial-mesenchymal transitions diversify non-cancerous lung cell behaviours

Epithelial-mesenchymal plasticity (EMP) is a hallmark of cancer. By enabling cells to shift between different morphological and functional states, EMP promotes invasion, metastasis and therapy resistance. We report that near-diploid non-cancerous human epithelial lung cells spontaneously shift along...

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Principais autores: Sugandha Bhatia, Jennifer H Gunter, Joshua T Burgess, Mark N Adams, Kenneth O'Byrne, Erik W Thompson, Pascal HG Duijf
פורמט: Artigo
שפה:Inglês
יצא לאור: Elsevier 2023-11-01
סדרה:Translational Oncology
נושאים:
Clonal diversity
Epigenetics
Epithelial-mesenchymal transition (EMT)
Epithelial-mesenchymal plasticity (EMP)
Intra-tumour heterogeneity
Metabolic reprogramming
גישה מקוונת:http://www.sciencedirect.com/science/article/pii/S1936523323001468
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