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In silico investigation of the mechanisms underlying atrial fibrillation due to impaired Pitx2.

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and is a major cause of stroke and morbidity. Recent genome-wide association studies have shown that paired-like homeodomain transcription factor 2 (Pitx2) to be strongly associated with AF. However, the mechanisms underlying P...

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Principais autores: Jieyun Bai, Andy Lo, Patrick A Gladding, Martin K Stiles, Vadim V Fedorov, Jichao Zhao
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science (PLoS) 2020-02-01
Serija:PLoS Computational Biology
Online dostop:https://doi.org/10.1371/journal.pcbi.1007678
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