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Innovative thiosemicarbazones that induce multi-modal mechanisms to down-regulate estrogen-, progesterone-, androgen- and prolactin-receptors in breast cancer

The estrogen receptor-α (ER-α) is a key driver of breast cancer (BC) and the ER-antagonist, tamoxifen, is a central pillar of BC treatment. However, cross-talk between ER-α, other hormone and growth factor receptors enables development of de novo resistance to tamoxifen. Herein, we mechanistically d...

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Principais autores: Faten Shehadeh-Tout, Heloisa H. Milioli, Suraya Roslan, Patric J. Jansson, Mahendiran Dharmasivam, Dinny Graham, Robin Anderson, Tharushi Wijesinghe, Mahan Gholam Azad, Des R. Richardson, Zaklina Kovacevic
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2023-07-01
Serier:Pharmacological Research
Fag:
Molecular pharmacology
Estrogen receptor
Tamoxifen
Thiosemicarbazones
Online adgang:http://www.sciencedirect.com/science/article/pii/S1043661823001627
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