Cellular cholesterol efflux is modulated by phospholipid-derived signaling molecules in familial HDL deficiency/Tangier disease fibroblasts

Familial HDL deficiency (FHD) is the heterozygous form of Tangier disease (TD). Mutations of the ABCA1 gene cause FHD and TD. FHD/TD cells are unable to normally efflux cholesterol onto nascent HDL particles, which are rapidly catabolized. TD fibroblasts have an abnormal pattern of PLC and PLD activ...

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主要な著者:	Bassam Haidar, Stephanie Mott, Betsie Boucher, Ching Yin Lee, Michel Marcil, Jacques Genest, Jr.
フォーマット:	Artigo
言語:	Inglês
出版事項:	Elsevier 2001-02-01
シリーズ:	Journal of Lipid Research
主題:	protein kinase C phospholipase C phospholipase D
オンライン･アクセス:	http://www.sciencedirect.com/science/article/pii/S0022227520316862
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