Doublecortin-like knockdown in mice attenuates obesity by stimulating energy expenditure in adipose tissue

Abstract Crosstalk between peripheral metabolic organs and the central nervous system is essential for body weight control. At the base of the hypothalamus, β-tanycytes surround the portal capillaries and function as gatekeepers to facilitate transfer of substances from the circulation into the cere...

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Auteurs principaux:	Melanie Modder, Claudia P. Coomans, Dirk-Jan Saaltink, Mayke M. H. Tersteeg, Janna Hoogduin, Leonie Scholten, Amanda C. M. Pronk, Reshma A. Lalai, Anita Boelen, Andries Kalsbeek, Patrick C. N. Rensen, Erno Vreugdenhil, Sander Kooijman
Format:	Artigo
Langue:	Inglês
Publié:	Nature Portfolio 2024-08-01
Collection:	Scientific Reports
Sujets:	Doublecortin-like β-Tanycytes Body weight control Energy expenditure White adipose tissue browning
Accès en ligne:	https://doi.org/10.1038/s41598-024-70639-5
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