Durable remission despite transplantation with active disease in therapy-related NUP98::TOP1-rearranged acute myeloid leukemia

Abstract Nucleoporin 98 (NUP98) rearrangements occur in approximately 2–3% of myeloid neoplasms and involve more than 40 partner genes. In acute myeloid leukemia (AML), they define distinct entities associated with adverse prognosis, high rates of chemoresistance, and frequent relapse even after all...

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Hauptverfasser:	Gaetano Cimino, Rebecca Sembenico, Francesco Zorutti, Simonetta Saldi, Matteo Caridi, Valeria Cardinali, Sofia Sciabolacci, Barbara Crescenzi, Caterina Matteucci, Roberta La Starza, Alessandra Pucciarini, Tiziana Zei, Roberta Iacucci Ostini, Cynthia Aristei, Alessandra Carotti, Cristina Mecucci, Loredana Ruggeri, Maria Paola Martelli, Antonio Pierini
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Springer 2026-05-01
Schriftenreihe:	Annals of Hematology
Schlagworte:	AML NUP98 rearrangements tAML allo-HSCT T-regulatory cells TMLI
Online-Zugang:	https://doi.org/10.1007/s00277-026-07073-2
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