Discovery of a subtype-selective, covalent inhibitor against palmitoylation pocket of TEAD3

The TEA domain (TEAD) family proteins (TEAD1‒4) are essential transcription factors that control cell differentiation and organ size in the Hippo pathway. Although the sequences and structures of TEAD family proteins are highly conserved, each TEAD isoform has unique physiological and pathological f...

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المؤلفون الرئيسيون:	Tian Lu, Yong Li, Wenchao Lu, TWGM Spitters, Xueyu Fang, Jun Wang, Simian Cai, Jing Gao, Yanting Zhou, Zhe Duan, Huan Xiong, Liping Liu, Qi Li, Hualiang Jiang, Kaixian Chen, Hu Zhou, Hua Lin, Huijin Feng, Bing Zhou, Christopher L. Antos, Cheng Luo
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	Elsevier 2021-10-01
سلاسل:	Acta Pharmaceutica Sinica B
الموضوعات:	Hippo pathway TEAD3 Covalent inhibitor Palmitoylation inhibitor.
الوصول للمادة أونلاين:	http://www.sciencedirect.com/science/article/pii/S2211383521001544
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!