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Discovery of a subtype-selective, covalent inhibitor against palmitoylation pocket of TEAD3

The TEA domain (TEAD) family proteins (TEAD1‒4) are essential transcription factors that control cell differentiation and organ size in the Hippo pathway. Although the sequences and structures of TEAD family proteins are highly conserved, each TEAD isoform has unique physiological and pathological f...

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Kaydedildi:
Asıl Yazarlar: Tian Lu, Yong Li, Wenchao Lu, TWGM Spitters, Xueyu Fang, Jun Wang, Simian Cai, Jing Gao, Yanting Zhou, Zhe Duan, Huan Xiong, Liping Liu, Qi Li, Hualiang Jiang, Kaixian Chen, Hu Zhou, Hua Lin, Huijin Feng, Bing Zhou, Christopher L. Antos, Cheng Luo
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Elsevier 2021-10-01
Seri Bilgileri:Acta Pharmaceutica Sinica B
Konular:
Hippo pathway
TEAD3
Covalent inhibitor
Palmitoylation inhibitor.
Online Erişim:http://www.sciencedirect.com/science/article/pii/S2211383521001544
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