Three-Month Administration of PB125 Modifies Histopathology, Redox Homeostasis, and Mobility in the Hartley Guinea Pig Model of Primary Osteoarthritis

The pathogenesis of primary osteoarthritis (OA) is complex and multifactorial. Nuclear factor erythroid 2-related factor-2 (Nrf2) is a transcription factor that regulates hundreds of genes involved with cytoprotection. The role of Nrf2 in OA remains undefined. We utilized the Hartley guinea pig mode...

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Principais autores:	Kendra M. Andrie, Robert V. Musci, Maureen A. Walsh, Sydney Bork, Zachary J. Valenti, Joseph Sanford, Margaret Campbell, Leila F. Afzali, Maryam F. Afzali, Karyn L. Hamilton, Kelly S. Santangelo
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2026-02-01
coleção:	Antioxidants
Assuntos:	Nrf2/ARE signaling Dunkin Hartley guinea pig osteoarthritis cartilage infrapatellar fat pad/synovial complex PB125
Acesso em linha:	https://www.mdpi.com/2076-3921/15/2/212
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