Single-cell long-read genotyping of transcripts reveals discrete mechanisms of clonal evolution in post-MPN AML

Abstract: Myeloproliferative neoplasms (MPNs) are caused by acquired mutations in hematopoietic stem and progenitor cells (HSPCs). The acquisition of additional mutations, such as TP53, and the overall mutational burden influence a patient’s risk of disease progression to lethal post-MPN acute myelo...

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Hlavní autoři:	Julian Grabek, Jasmin Straube, Leanne Cooper, Rohit Haldar, Ranran Zhang, Inken Dulige, Matthew Barker, Will Gatehouse, Helen Christensen, Gerlinda Amor, Victoria Y. Ling, Caroline McNamara, David M. Ross, Andrew Perkins, Megan J. Bywater, Steven W. Lane
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2026-07-01
Edice:	Blood Advances
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2473952926003502
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